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Tetracycline Hydrochloride

Tetracycline Hydrochloride

Synonyms Achromycin HCl; Polucycline HCl; [4S-(4a, 4aa, 5aa, 6b, 12aa)]- 4-(Dimethylamino)- 1, 4, 4a, 5, 5a, 6-11, 12a-octahydro-3, 6, 10, 12, 12a-pentahydroxy- 6- methyl-1, 11-dioxo-2-naphthacenecarboxamide hydrochloride; Achro; Achromycin; Achromycin V; Ala Tet; Ambracyn; Ambramicina; Bristaciclina; Cefracycline; Criseociclina; Cyclopar; Diocyclin; Helvecyclin; Hostacyclin; Imex; Mediletten; Mephacyclin; Panmycin; Partrex; Polycycline; Purocyclina; Quadracyclin; Remicyclin; Riocyclin; Ro-Cycline; Sanclomycine; Steclin; Sumycin; Supramycin; Sustamycin; Tefilin; Tetrabakat; Tetrabid; Tetrablet; Tetrabon; Tetrachel; Tetracompren; Tetracyn; Tetrakap; Tetralution; Tetramavan; Tetramycin; Tetrosol; Topicycline; Totomycin; Triphacyclin; Unicin; Vetquamycin-324

CAS Number: 64-75-5 Molecular Formula: C22H24N2O8·HCl Molecular Weight: 480.898 g/mol

Beilstein Registry Number: 3844873 EC Number: 200-593-8 MDL Number: MFCD00078142

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SKU 02103011-CF
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Description

Product Description

Tetracycline Hydrochloride

Application Notes

Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Specifications
SKU 02103011-CF
Application Notes Tetracycline is a broad spectrum polyketide antibiotic with clinical uses in treating bacterial infections such as Rocky Mountain spotted fever, typush fever, tick fevers, Q fever, and Brill-Zinsser disease and to treat upper respiratory infections and acne. It has been used in studies of multidrug resistance and potential side effects including acute pancreatitis.
Beilstein Registry Number 3844873
Biochemical Physiological Actions Mode of Action: Tetracycline passively diffuses through proin channels in the cell membrane, binding to 30S ribosomes and inhibits protein synthesis by preventing access of aminoacyl tRNA to the acceptor site on the mRNA-ribosome complex. It also binds to the bacterial 50S ribosomal subunit, altering the membrane and causing intracellular components to leak from bacterial cells. The inhibitory effects can be reversed by washing, suggesting that it is the reversibly bound antibiotic, and not the irreversibly bound drug, that is responsible for antibacterial action.Mode of Resistance: The effects are inactivated via a loss of cell wall permeability.Antimicrobial spectrum: Includes a wide range of antimicrobial activity against gram-positive and gram-negative bacteria.
EC Number 200-593-8
Extinction Coefficient EMm (220nm) = 13 (free base in 0.1 M HCl); EmM (268nm) = 18.04 (free base in 0.1 M HCl); EmM (355nm) = 13.32 (free base in 0.1 M HCl)(Lit.)
Format powder
Hazard Statements H315-H319-H335
Melting Point 417° F (decomposes) (NTP, 1992)
Moisture Content ≤2%
Molecular Formula C22H24N2O8·HCl
Molecular Weight 480.898 g/mol
Optical Rotation -239 ° to -258 ° (c=0.01, 0.1 N HCl)
Personal Protective Equipment Dust mask, Eyeshields, Gloves
pH 3.0-7.0 /saturated solution/
Physical Appearance Yellow Powder
pKa (50% aq DMF): 8.3, 10.2 (Lit.)
Potency ≥900 µg/mg
Product Families Description Tetracycline
Product Overview Tetracycline Hydrochloride
RTECS Number QI9100000
Safety Symbol GHS07
Solubility 50 to 100 mg/mL at 72° F (NTP, 1992)
Storage and Handling 0°C; protect from light
Typical Working Concentration 10 mg/L
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UV Visible Absorbance λ max (1N HCl) 219, 271, 357 ± 5 nm