Dino

Methotrexate

Methotrexate

Synonyms Amethopterin; N-[4-[[(2,4-Diamino-6-pteridinyl) methyl] methylamino] benzoyl]-L- glutamic acid; 4-amino-N10-methylpteroylglutamic acid; 4-amino-10-methylfolic acid; methylaminopterin; MTX; CL-14377; Emtexate; Ledertrexate; A-Methopterin; Rheumatrex

CAS Number: 59-05-2 Molecular Formula: C20H22N8O5 Molecular Weight: 454.447 g/mol

EC Number: 200-413-8 MDL Number: MFCD00064370

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SKU 02102299-CF
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Description

Product Description

Methotrexate

Application Notes

Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites. Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Anti-tumor studies.

Specifications
SKU 02102299-CF
Application Notes Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites. Potent inhibitor of dihydrofolate reductase and agent for antitumor studies. Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Biochemical Physiological Actions Methotrexate is an allosteric inhibititor of dihydrofolate reductase (DHFR), the enzyme that catalyzes the conversion of dihydrofolate to tetrahydrofolate. Since tetrahydrolfolate is required for purine and pyrimidine synthesis, methotrexate treatment results in the inhibition of DNA and RNA synthesis.
EC Number 200-413-8
Format powder
Grade USP
Applications Anti-tumor studies.
Melting Point 365 to 399° F (decomposes) (NTP, 1992)
Molecular Formula C20H22N8O5
Molecular Weight 454.447 g/mol
Optical Rotation +19° to +24°
Physical Appearance Orange Powder
Product Families Description Methotrexate
Product Overview Methotrexate
Purity ≥98%
Residue on Ignition ≤0.1%
RTECS Number MA1225000
Solubility less than 1 mg/mL at 66° F (NTP, 1992)
Storage and Handling +4 °C
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Vapor Pressure 2.1X10-19 mm Hg at 25 deg C /Estimated/