Intrinsic Factor

Intrinsic Factor

Synonyms IF; Vitamin B12-binding protein

CAS Number: 2596481

EC Number: 232-711-9 MDL Number: MFCD00131406

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SKU 02102056-CF
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Description

Product Description

Intrinsic Factor

Application Notes

Intrinsic Factor is used in the treatment not only of classical pernicious anaemia, but also in the treatment of other macrocytic anaemias, where it replaces teh Intrinsic Factor which may be lacking in the patient's own gastric juice. In this way Intrinsic Factor is recommended against anaemias that appear 6 to 12 months after serious gastric operations, and against anaemias that are secondary effects of the treatment with certain medicines, e.g. against epilepsy. However, the dietetic use in multi-vitamin preparations is of the greatest importance. In older people there has been observed a degeneration of the gastric mucous membrane, whose secretion of Intrinsic Factor is insufficient to ensure the resorption of the necessary quantity of B-12 from their diet. In order to delay this development it is useful to prescribe a small quantity of Intrinsic Factor with B-12 and other vitamins to these patients.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Absorption of vitamin B12

Specifications
SKU 02102056-CF
Alternate Names IF; Vitamin B12-binding protein
Application Notes Intrinsic Factor is used in the treatment not only of classical pernicious anaemia, but also in the treatment of other macrocytic anaemias, where it replaces teh Intrinsic Factor which may be lacking in the patient's own gastric juice. In this way Intrinsic Factor is recommended against anaemias that appear 6 to 12 months after serious gastric operations, and against anaemias that are secondary effects of the treatment with certain medicines, e.g. against epilepsy. However, the dietetic use in multi-vitamin preparations is of the greatest importance. In older people there has been observed a degeneration of the gastric mucous membrane, whose secretion of Intrinsic Factor is insufficient to ensure the resorption of the necessary quantity of B-12 from their diet. In order to delay this development it is useful to prescribe a small quantity of Intrinsic Factor with B-12 and other vitamins to these patients.
EC Number 232-711-9
Foreign Activity Salmonella=Negative; E. coli=Negative
Format powder
Applications Absorption of vitamin B12
MDL # MFCD00131406
Personal Protective Equipment Eyeshields, Gloves,respirator filter
Physical Appearance Tan Powder
Preparation Method MP Intrinsic Factor is produced from the pylorus mucous membrane of the pig, of which only a small part is used. Only the part which, according to histological examinations has proved to have a high content of Intrinsic Factor, is used.
Product Families Description Intrinsic factor
Product Overview Intrinsic Factor
Source Porcine Pyloric Mucous Lining
Storage and Handling -20°C
Unit Definition The activity is normally indicated in Coli units, the number of which are proportional to the binding power of the substance to Vitamin B-12.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.