Hydroxyurea

Hydroxyurea

Synonyms Hydroxycarbamide; Carrbamoyl Oxime; N-(Aminocarbonyl) Hydroxyamine; Oxyurea

CAS Number: 127-07-1 Molecular Formula: CH4N2O2

Beilstein Registry Number: 1741548 EC Number: 204-821-7 MDL Number: MFCD00007943

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SKU 02102023-CF
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Description

Product Description

Hydroxyurea

Application Notes

Hydroxyurea induces apoptosis of in vitro myelogenous leukemia lymphocytes, and the phosphorylation of FADD and p53. It is also used to reduce the rate of painful attacks in sickle-cell disease and has antiretroviral properties in diseases such as AIDS.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Cancer Research||Apoptosis and Cell Cycle

Specifications
SKU 02102023-CF
Alternate Names Hydroxycarbamide; Carrbamoyl Oxime; N-(Aminocarbonyl) Hydroxyamine; Oxyurea
Application Notes Hydroxyurea induces apoptosis of in vitro myelogenous leukemia lymphocytes, and the phosphorylation of FADD and p53. It is also used to reduce the rate of painful attacks in sickle-cell disease and has antiretroviral properties in diseases such as AIDS.
Beilstein Registry Number 1741548
Biochemical Physiological Actions Anti-neoplastic. Inactivates ribonucleoside reductase by forming a free radical nitroxide that binds a tyrosyl free radical in the active site of the enzyme. This blocks the synthesis of deoxynucleotides, which inhibits DNA synthesis and induces synchronization or cell death in S-phase.
EC Number 204-821-7
Format Crystalline powder
Hazard Statements H361
Applications Cancer Research||Apoptosis and Cell Cycle
MDL # MFCD00007943
Molecular Formula CH4N2O2
Personal Protective Equipment Eyeshields, Full-face particle respirator, Gloves, Respirator cartridge, Respirator filter
Physical Appearance White Crystalline Powder
Product Families Description Hydroxyurea
Product Overview Hydroxyurea
RTECS Number YT4900000
Safety Symbol GHS08
Storage and Handling Store at +4 °C.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.