L-Histidine Monohydrochloride Monohydrate

L-Histidine Monohydrochloride Monohydrate

Synonyms L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride; (S)-α-amino-1H-imidazole-4-propanoic acid hydrochloride; glyoxaline-5-alanine hydrochloride;His;H

CAS Number: 5934-29-2 Molecular Formula: C6H9N3O2 • HCl • H2O Molecular Weight: 209.63 g/mol

Beilstein Registry Number: 4168261 MDL Number: MFCD00151027

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SKU 02101957-CF
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Description

Product Description

L-Histidine Monohydrochloride Monohydrate

Application Notes

L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis. Exogenous histidine has been shown to enhance the biosynthesis of lovastatin by cultured Aspergillus terreus. Histidine has been utilized as a single nitrogen source to probe swarming in Pseudomonas aeruginosa on agar. An in vivo study has used L-histidine to diminish the net secretory response of the small intestine of of cholera toxin-challenged mice.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Specifications
SKU 02101957-CF
Alternate Names L-α-Amino-β-(4-imidazolyl)propionic acid monohydrochloride; (S)-α-amino-1H-imidazole-4-propanoic acid hydrochloride; glyoxaline-5-alanine hydrochloride;His;H
Application Notes L-Histidine has been used to study cultures of the human T-lymphoblastic leukemia cell line MOLT-4 to study modulation of apoptosis. Exogenous histidine has been shown to enhance the biosynthesis of lovastatin by cultured Aspergillus terreus. Histidine has been utilized as a single nitrogen source to probe swarming in Pseudomonas aeruginosa on agar. An in vivo study has used L-histidine to diminish the net secretory response of the small intestine of of cholera toxin-challenged mice.
Beilstein Registry Number 4168261
Biochemical Physiological Actions Because the pKa of the imidazole group is close to physiological pH, the imidazole moiety can be either uncharged or positively charged, depending on the local environment. This property makes histidine residues of exceptional interest in the active sites of many proteins, such as hemoglobin and myoglobin, where the imidazole ring can readily alternate between the charged (imidazolium) and uncharged (imidazole) states to participate in bond formation and breakage. Histidine is biosynthesized from ATP, 5-phosphoribosyl-1-pyrophosphate (PRPP), and glutamine. In turn, histidine is degraded to glutamate by histidase, urocanase, and imidazolonepropionase via the formation of urocanate, 4-imidazolone 5-propionate, and N-formiminoglutamate.
Format powder
Isoelectric Point 7.641(Lit.)
Loss on Drying ≤1%
MDL # MFCD00151027
Molecular Formula C6H9N3O2 • HCl • H2O
Molecular Weight 209.63 g/mol
Optical Rotation +9.5° ± 1° (c = 1, 6NHCl)
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance White Powder
pKa 1.80 (COOH), 9.33 (NH2), 6.04 (imidazole group)(Lit.)
Product Families Description L-Histidine
Product Overview L-Histidine Monohydrochloride Monohydrate
RTECS Number MS3119000
Storage and Handling Store at Room Temperature (15-30 °C).
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.