L-Glutamic Acid

L-Glutamic Acid

Synonyms L-2-Aminopentanedioic acid; (S)-(+)-glutamic acid; L-Glu; Glu; (S)-2-Aminopentanedioic acid; a-aminoglutaric acid; 1-aminopropane-1,3- dicarboxylic acid; Glu; E

CAS Number: 142-47-2 Molecular Formula: C5H9NO4 Molecular Weight: 169.112 g/mol

Beilstein Registry Number: 1723801 EC Number: 200-293-7 MDL Number: MFCD00002634

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SKU 02101793-CF
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Description

Product Description

L-Glutamic Acid

Application Notes

It is often used as a food additive and flavour enhancer in the form of its salt, known as monosodium glutamate (MSG). A glutamic acid derivative, poly-γ-benzyl-L-glutamate (PBLG), is often used as an alignment medium to control the scale of the dipolar interactions observed. L-Glutamic acid is used in cell culture as a component of MEM non-essential amino acids solution. L-Glutamic acid has been used as a nitrogen source in the culture of Aspergillus fumigatus NRRL 2436 for fumagillin production. The competitive roles of L-glutamic acid and L-aspartic acid in the growth of Oenococcus oeni NCFB 1707 have been studied.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Neuroscience||Neurotransmission

Specifications
SKU 02101793-CF
Application Notes It is often used as a food additive and flavour enhancer in the form of its salt, known as monosodium glutamate (MSG). A glutamic acid derivative, poly-γ-benzyl-L-glutamate (PBLG), is often used as an alignment medium to control the scale of the dipolar interactions observed. L-Glutamic acid is used in cell culture as a component of MEM non-essential amino acids solution. L-Glutamic acid has been used as a nitrogen source in the culture of Aspergillus fumigatus NRRL 2436 for fumagillin production. The competitive roles of L-glutamic acid and L-aspartic acid in the growth of Oenococcus oeni NCFB 1707 have been studied.
Beilstein Registry Number 1723801
Biochemical Physiological Actions An excitatory amino acid neurotransmitter that is an agonist at all subtypes of glutamate receptors (metabotropic, kainate, NMDA, and AMPA). Glutamate is a key compound in cellular metabolism. It is the most abundant excitatory neurotransmitter in the vertebrate nervous system. It also serves as the precursor for the synthesis of the inhibitory GABA in GABA-ergic neurons. This reaction is catalyzed by glutamate decarboxylase (GAD), which is most abundant in the cerebellum and pancreas.
Boiling Point 225 deg C (decomposes)
Density 26.2 (saturated <a class="pubchem-internal-link CID-962" href="https://pubchem.ncbi.nlm.nih.gov/compound/water">water</a> solution at 20 deg C)
EC Number 200-293-7
Format Free Acid; Powder
Gene ID human ... CCR2(1231), GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK2(2898), GRIK3(2899), GRIK5(2901), GRIN2B(2904), GRM2(2912), SLC1A1(6505), SLC1A2(6506) rat ... Gria1(50592), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grm1(24414), Grm2(24415), Grm3(24416), Grm4(24417), Grm5(24418), Grm6(24419), Grm7(81672), Slc1a2(29482)
Heavy Metals ≤20 ppm (as Pb)
Isoelectric Point 3.08 (Lit.)
Applications Neuroscience||Neurotransmission
Melting Point 450° F (Decomposes) (NTP, 1992)
Moisture Content ≤0.15%
Molecular Formula C5H9NO4
Molecular Weight 169.112 g/mol
Optical Rotation +25° to +35° (c=10, 2N HCl )
Personal Protective Equipment Eyeshields, Gloves, Respirator filter
pH Between 6,7 and 7,2 (5 % solution)
Physical Appearance White Powder
pKa 2.10 (α-COOH), 9.47 (α-NH2), 4.07 (φ-COOH) (Lit.)
Product Families Description L-Glutamic acid
Product Overview L-Glutamic Acid
Purity ≥99%
RTECS Number LZ9700000
Solubility greater than or equal to 100 mg/mL at 68° F (NTP, 1992)
Storage and Handling Store at Room Temperature (15-30 °C).
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.