Dino

5-Fluorouracil

5-Fluorouracil

Synonyms 2,4-Dihydroxy-5-fluoropyrimidine; 5-Fluoro-2,4(1H,3H)-pyrimidinedione; 5-FU

CAS Number: 51-21-8 Molecular Formula: C4H3FN2O2 Molecular Weight: 130.078 g/mol

Beilstein Registry Number: 127172 EC Number: 200-085-6 MDL Number: MFCD00006018

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SKU 02101722-CF
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Description

Product Description

5-Fluorouracil

Application Notes

5-Fluorouracil (5-FU) inhibits the activity of thymidylate synthetase, which affects pyrimidine synthesis and leads to depletion of intracellular TTP pools. 5-FU has also been proposed to interfere with the activity of ribosomal RNA binding protein (RRBP), at the level of pre-ribosomal RNA (pre-rRNA) processing. 5-Fluorouracil is a potent agent against solid tumors that was introduced in 1957 for clinical use. It remains one of the most effective chemotherapeutic agents in such conditions as colorectal cancer, even at its limited response rates (10 - 30%).

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Inhibits the activity of thymidylate synthetase

Specifications
SKU 02101722-CF
Application Notes 5-Fluorouracil (5-FU) inhibits the activity of thymidylate synthetase, which affects pyrimidine synthesis and leads to depletion of intracellular TTP pools. 5-FU has also been proposed to interfere with the activity of ribosomal RNA binding protein (RRBP), at the level of pre-ribosomal RNA (pre-rRNA) processing. 5-Fluorouracil is a potent agent against solid tumors that was introduced in 1957 for clinical use. It remains one of the most effective chemotherapeutic agents in such conditions as colorectal cancer, even at its limited response rates (10 - 30%).
Beilstein Registry Number 127172
Biochemical Physiological Actions A potent antitumor agent that affects pyrimidine synthesis by inhibiting thymidylate synthetase thus depleting intracellular dTTP pools. It is metabolized to ribonucleotides and deoxyribonucleotides, which can be incorporated into RNA and DNA. Treatment of cells with 5-FU leads to an accumulation of cells in S-phase and has been shown to induce p53 dependent apoptosis.
Boiling Point Decomposes at 282-283 deg C; sublimes (0.1 mm): 190-200 deg C
EC Number 200-085-6
Extinction Coefficient EmM = 7.07 (0.1 M HCl)(Lit.)
Format powder
Hazard Statements H301-H412
Applications Inhibits the activity of thymidylate synthetase
Melting Point Decomposes at 540-541° F (EPA, 1998)
Molecular Formula C4H3FN2O2
Molecular Weight 130.078 g/mol
Physical Appearance White Powder
pKa 8.0 (Lit.)
Product Families Description 5-Fluorouracil
Product Overview 5-Fluorouracil
Purity ~99%
RTECS Number YR0350000
Safety Symbol GHS06
Solubility less than 1 mg/mL at 66° F (NTP, 1992)
Storage and Handling Store at Room Temperature (15-30 °C). Protect from light.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UV Visible Absorbance λ max: 265 nm (Lit.)
Vapor Pressure 2.68X10-6 mm Hg at 25 deg C (est)