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Dextran Sulfate Sodium Salt (8,000 M.Wt)

Dextran Sulfate Sodium Salt (8,000 M.Wt)

Synonyms Dextran sodium sulfate; DSS

CAS Number: 9011-18-1 Molecular Weight: 165.192 g/mol

MDL Number: MFCD00081551

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SKU 02101516-CF
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Description

Product Description

Dextran Sulfate Sodium Salt (8,000 M.Wt)

Application Notes

Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used as an anticoagulant, antiviral as well as antilipemic agent.Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein. Exhibits activity as an adjuvant.Antiviral and Antienzyme Activity – Baba et al., have shown in In Vitro studies that DSS inhibits the binding of various enveloped viruses including Human Immunodeficiency Virus (HIV), Herpes Virus (HSV) and Cytomegalovirus (CMV) to cells. Additionally, DSS has also shown to exhibit a potent inhibitory effect on many enzymes, for example hyaluronidase, adenylate cyclase, and amylase. Hofer at al., have shown that DSS induces bacterial translocation in HIV-infected humanized mice.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Immunology||Antiviral||Antilipemic||Anticoagulant

Specifications
SKU 02101516-CF
Application Notes Dextran Sulfate Sodium (DSS) which has proven to have versatile value in Biomedical/clinical research. DSS can be used as an anticoagulant, antiviral as well as antilipemic agent.Dextran sulfate sodium shows immunologically relevant activities: enhancement and suppression of humoral immunity, polyclonal activation of B-lymphocytes, stimulating even immature B cells, changes in thymocyte reactivity to lectins, enhancement/suppression of cell-mediated immune responses. Precipitates LDL and VLDL lipoproteins - in the presence of magnesium ions, dextran sulfate precipitates low-density lipoproteins from human serum leaving the high-density lipoproteins in the supernatant. Removal of lipoproteins by dextran sulfate precipitation may be useful in the purification of other materials such as beta 2 glycoprotein. Exhibits activity as an adjuvant.Antiviral and Antienzyme Activity – Baba et al., have shown in In Vitro studies that DSS inhibits the binding of various enveloped viruses including Human Immunodeficiency Virus (HIV), Herpes Virus (HSV) and Cytomegalovirus (CMV) to cells. Additionally, DSS has also shown to exhibit a potent inhibitory effect on many enzymes, for example hyaluronidase, adenylate cyclase, and amylase. Hofer at al., have shown that DSS induces bacterial translocation in HIV-infected humanized mice.
Boiling Point 310 °C
Grade Reagent Grade
Applications Immunology||Antiviral||Antilipemic||Anticoagulant
Loss on Drying <10%
Melting Point 92 °C
Molecular Weight 165.192 g/mol
Optical Rotation +75 ° to 105 °
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance White powder
Product Families Description Dextran sulfate sodium salt
Product Overview Dextran Sulfate Sodium Salt (8,000 M.Wt)
Residue on Ignition 35 - 50%
RTECS Number HH9290000
Solubility >24.8 [ug/mL]
Storage and Handling Store at Room Temperature (15-30 °C)
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Vapor Pressure 2.6X10-4 mm Hg at 25 deg C /Estimated/