Butylated Hydroxytoluene

Butylated Hydroxytoluene

Synonyms 2,6-Di-tert-Butyl-p-Cresol; BHT; 2,6-Di-t-Butyl-4-MethylPhenol; Butylhydroxytoluene; DBPC; 2,6-Di-tert-butyl-4-methylphenol; 2,6-bis(1,1-Dimethylethyl)-4-methylphenol

CAS Number: 128-37-0 Molecular Formula: C15H24O Molecular Weight: 220.356 g/mol

Beilstein Registry Number: 1911640 EC Number: 204-881-4 MDL Number: MFCD00011644

SKU 02101162-CF
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Product Description

Butylated Hydroxytoluene

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications


SKU 02101162-CF
Beilstein Registry Number 1911640
Biochemical Physiological Actions Butylated hydroxytoluene (BHT) has been shown to inhibit lipid peroxidation. It causes lung injury and promotes tumors in mice, but this may be due to a metabolite of BHT, 6-tert-butyl-2-[2′-(2′-hydroxymethyl)-propyl]-4-methylphenol. Metabolites of BHT have also been reported to induce DNA strand breaks and internucleosomal DNA fragmentation (a characteristic of apoptosis) in cultured cells. In rats, a single intraperitoneal injection of BHT (60 mg/kg body mass) results in a significant increase in nuclear DNA methyl transferase activity in the liver, kidneys, heart, spleen, brain and lungs. Incubation of alveolar macrophages with BHT significantly reduced the level of TNF-α which may explain the mechanism by which this antioxidant reduces inflammation. Preincubation of aspirin-treated platelets with BHT inhibits the secretion, aggregation, and protein phosphorylation induced by protein kinase C activators. BHT was also found to inhibit the initiation of hepatocarcinogenesis by aflatoxin B1.
Boiling Point 509° F at 760 mm Hg (NTP, 1992)
Density 1.048 at 68° F (NTP, 1992)
EC Number 204-881-4
Extinction Coefficient EmM(278 nm)=1.75-1.83 (in methanol)(Lit.)
Flash Point 260° F (NTP, 1992)
Format Crystalline powder
Hazard Statements H302-H315-H319-H411
Applications Antioxidant
Melting Point 156 to 160° F (NTP, 1992)
Molecular Formula C15H24O
Molecular Weight 220.356 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Physical Appearance White Crystalline Powder
Product Families Description Butylated hydroxytoluene
Product Overview Butylated Hydroxytoluene
RTECS Number GO7875000
Safety Symbol GHS07, GHS09
Solubility less than 1 mg/mL at 68° F (NTP, 1992)
Storage and Handling Store at Room Temperature (15-30 °C).
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Vapor Density 7.6 (Air = 1)
Vapor Pressure 0.01 mm Hg (NIOSH, 2016)