Dino

Streptokinase

Streptokinase

Synonyms Streptokinase from Streptococcus hemolyticus; Arvelysin; Kabikinase; Streptase; Streptococcal firbinoysin

CAS Number: 2593954 Molecular Weight: 47400 (Lit.)

EC Number: 232-647-1 MDL Number: MFCD00082037

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SKU 02101114-CF
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Description

Product Description

Streptokinase catalyzes hydrolysis of amide linkages. Forms a 1:1 complex with plasminogen which is then converted to streptokinase-plasmin. Both streptokinase-plasminogen and streptokinase-plasmin complexes can activate plasminogen. As a result of its interaction with human or rabbit plasminogen, streptokinase undergoes specific fragmentation.

Application Notes

Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Thrombolytic agent

Specifications
SKU 02101114-CF
Application Notes Streptokinase is commonly used as a thrombolytic agent in the therapy of ischemic stroke. This therapy carries the important risk of intracerebral hemorrhage. Streptokinase is also used in the treatment of complicated parapneumonic effusions and empyema where adverse reactions, allergic type, are rare
EC Number 232-647-1
Format Lyophilized solid
Applications Thrombolytic agent
Molecular Weight 47400 (Lit.)
Physical Appearance White Lyophilized Powder
RTECS Number OB8880000
Solubility Soluble in water
Source Lancefield group C strain of Streptococcus
Specific Activity ≥5,000 units/mg dry weight
Storage and Handling Store at -20 °C; protect from light.
Unit Definition One unit is defined as the amount of enzyme that will liquefy a standard clot of fibrinogen, plasminogen and thrombin in 10 minutes at 37 °C and pH 7.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.