Betaine

Betaine

Synonyms Lycine; Oxyneurine; (Carboxymethyl)trimethylammonium inner salt; Glycine betaine; 1-carboxy-N,N,N-trimethylmethanammonium inner salt

CAS Number: 107-43-7 Molecular Formula: C5H11NO2 Molecular Weight: 117.148 g/mol

Beilstein Registry Number: 3537113 EC Number: 203-490-6 MDL Number: MFCD00012123

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SKU 02101003-CF
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Description

Product Description

Betaine

Application Notes

Betaine is a reagent that is used in soldering, resin curing fluxes, and organic synthesis. Betaine has been studied in its role in protecting plants from environmental stress and in maintaining osmolarity in mammalian cells. Betaine has been reported to diminish the base pair composition dependence of DNA thermal melting transitions, with a concentration of 5.2 M betaine being the value at which AT and GC base pairs are equally stable and hence subsequently found application in the polymerase chain reaction (PCR). The usefulness of betaine in PCR has resulted from its ability to enhance DNA amplification by diminishing the formation of secondary structure in GC-rich DNA regions. A protocol for the production of long-chain cDNAs that uses betaine and trehalose has been published. The permanent positive charge on betaine makes it a target of study for mass spectrometry (MS) analysis by such methods as electrospray ionization (ESI) MS.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Specifications
SKU 02101003-CF
Alternate Names Lycine; Oxyneurine; (Carboxymethyl)trimethylammonium inner salt; Glycine betaine; 1-carboxy-N,N,N-trimethylmethanammonium inner salt
Application Notes Betaine is a reagent that is used in soldering, resin curing fluxes, and organic synthesis. Betaine has been studied in its role in protecting plants from environmental stress and in maintaining osmolarity in mammalian cells. Betaine has been reported to diminish the base pair composition dependence of DNA thermal melting transitions, with a concentration of 5.2 M betaine being the value at which AT and GC base pairs are equally stable and hence subsequently found application in the polymerase chain reaction (PCR). The usefulness of betaine in PCR has resulted from its ability to enhance DNA amplification by diminishing the formation of secondary structure in GC-rich DNA regions. A protocol for the production of long-chain cDNAs that uses betaine and trehalose has been published. The permanent positive charge on betaine makes it a target of study for mass spectrometry (MS) analysis by such methods as electrospray ionization (ESI) MS.
Beilstein Registry Number 3537113
Biochemical Physiological Actions End-product of oxidative metabolism of choline, betaine is a general methyl donor, in particular in a minor pathway of methionine biosynthesis. It is used to treat homocystinuria, which is a defect in the major pathway of methionine biosynthesis.
EC Number 203-490-6
Format powder
Grade Anhydrous
MDL # MFCD00012123
Melting Point Decomposes around 293 deg C
Moisture Content ≤1%
Molecular Formula C5H11NO2
Molecular Weight 117.148 g/mol
Personal Protective Equipment Eyeshields, Gloves, respirator filter
Physical Appearance White Powder
pKa 1.83 (Lit.)
Product Families Description Betaine
Product Overview Betaine
RTECS Number DS5900000
Solubility Solubility (g/100 g solvent): <a class="pubchem-internal-link CID-887" href="https://pubchem.ncbi.nlm.nih.gov/compound/methanol">methanol</a>, 55; <a class="pubchem-internal-link CID-702" href="https://pubchem.ncbi.nlm.nih.gov/compound/ethanol">ethanol</a>, 8.7. Sparingly soluble in ether.
Storage and Handling Store at +4 °C; desiccate.
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.
Vapor Pressure 1.36X10-8 mm Hg at 25 deg C (est)