5-Azacytidine

5-Azacytidine

Synonyms 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 5-Azacitidine; Ladakamycin

CAS Number: 320-67-2 Molecular Formula: C8H12N4O5 Molecular Weight: 244.207 g/mol

Beilstein Registry Number: 620461 EC Number: 206-280-2 MDL Number: MFCD00006539

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SKU 02100821-CF
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Description

Product Description

5-Azacytidine

Application Notes

5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Inhibition of protein synthesis||bacteriostatic||antitumor||mutagenic agent

Specifications
SKU 02100821-CF
Alternate Names 4-Amino-1-(β-D-ribofuranosyl)-1,3,5-triazin-2(1H)-one; 5-Azacitidine; Ladakamycin
Application Notes 5-Azacytidine, its incorporation into RNA alters RNA synthesis and processing, and results in inhibition of protein synthesis. It has been used as a cancer chemotherapeutic agent. It is a powerful bacteriostatic, antitumor, and mutagenic agent; it also exhibits immunosuppressive, antimitotic, radioprotective, and virostatic effects.
Beilstein Registry Number 620461
Biochemical Physiological Actions A potent growth inhibitor and cytotoxic agent; inhibits DNA methyltransferase, an important regulatory mechanism of gene expression, gene activation and silencing. Causes DNA demethylation or hemi-demethylation, creating openings that allow transcription factors to bind to DNA and reactivate tumor suppressor genes
EC Number 206-280-2
Format powder
Hazard Statements H302-H350
Applications Inhibition of protein synthesis||bacteriostatic||antitumor||mutagenic agent
MDL # MFCD00006539
Melting Point 442 to 446° F (decomposes) (NTP, 1992)
Molecular Formula C8H12N4O5
Molecular Weight 244.207 g/mol
Personal Protective Equipment Eyeshields, full-face particle respirator , Gloves, respirator cartridge, respirator filter
Physical Appearance White Powder
Product Families Description 5-Azacytidine
Product Overview 5-Azacytidine
RTECS Number XZ3017500
Safety Symbol GHS07, GHS08
Solubility >36.6 [ug/mL]
Storage and Handling Store at 0 °C.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.