Polymyxin B Sulfate

Polymyxin B Sulfate

Synonyms Aerosporin

CAS Number: 1405-20-5 Molecular Formula: C55H96N16O13·2H2SO4 Molecular Weight: 1301.571 g/mol

EC Number: 215-774-7 MDL Number: MFCD00131991

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SKU 02100565-CF
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Description

Product Description

Polymyxin B Sulfate

Application Notes

Polymyxin B sulfate is a mixture of Polymyxin B1 and B2 sulfate. It is used clinically to treat infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. It is used to study multidrug-resistant pathogens.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Cell culture

Specifications
SKU 02100565-CF
Alternate Names Aerosporin
Application Notes Polymyxin B sulfate is a mixture of Polymyxin B1 and B2 sulfate. It is used clinically to treat infections of the urinary tract, meninges, and blood stream, caused by susceptible strains of Pseudomonas aeruginosa. It is used to study multidrug-resistant pathogens.
Biochemical Physiological Actions Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.
EC Number 215-774-7
Format powder
Hazard Statements H302
Applications Cell culture
Loss on Drying ≤8%
MDL # MFCD00131991
Molecular Formula C55H96N16O13·2H2SO4
Molecular Weight 1301.571 g/mol
Personal Protective Equipment Dust mask, Eyeshields, Gloves
Physical Appearance White powder
pKa 43227
Product Families Description Polymixin-B-sulfate
Product Overview Polymyxin B Sulfate
RTECS Number TR1150000
Solubility Water Solubility25 mg/mL
Source Soluble in water; 1 mM HCl
Storage and Handling +4°C; desiccate
Unit Definition Effective concentration is typically 50 mg/L.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.