Streptozotocin

Streptozotocin

Synonyms N-(Methylnitrosocarbamoyl)-α-D-glucosamine; Streptozocin; STZ; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose

CAS Number: 18883-66-4 Molecular Formula: C8H15N3O7 Molecular Weight: 265.222 g/mol

Beilstein Registry Number: 2060675 EC Number: 242-646-8 MDL Number: MFCD00006607

SKU 02100557-CF
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Description

Product Description

Streptozotocin

Application Notes

Streptozocin is used to induce Type 1 diabetes for medical research. It has been used for the treatment of malignant insulinoma It is used mainly in the treatment of pancreatic (islet-cell) tumors.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Treatment of pancreatic (islet-cell) tumors

Specifications
SKU 02100557-CF
Alternate Names N-(Methylnitrosocarbamoyl)-α-D-glucosamine; Streptozocin; STZ; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose
Application Notes Streptozocin is used to induce Type 1 diabetes for medical research. It has been used for the treatment of malignant insulinoma It is used mainly in the treatment of pancreatic (islet-cell) tumors.
Base Catalog Number 100557
Beilstein Registry Number 2060675
Biochemical Physiological Actions An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
CAS # 18883-66-4
EC Number 242-646-8
Extinction Coefficient EmM(228 nm): 6.36 (ethanol)
Format powder
Half Life biological half-life in cell culture medium was shown to be approximately 19 minutes.
Hazard Statements H350
Applications Treatment of pancreatic (islet-cell) tumors
Melting Point 239° F (Decomposes) (NTP, 1992)
Molecular Formula C8H15N3O7
Molecular Weight 265.222 g/mol
Personal Protective Equipment Eyeshields, full-face particle respirator type N100, Gloves, respirator cartridge, respirator filter
Physical Appearance Off-white powder
Product Families Description Streptozotocin
Product Overview Streptozotocin
Purity ~75% α-anomer basis; ≥97%
RTECS Number LZ5775000
Safety Symbol GHS06+GHS08
Solubility Soluble (NTP, 1992)
Storage and Handling -20°C; desiccate; store under nitrogen
Typical Working Concentration Has been used in intravenous injections in rats at a dose of 65 mg/kg body weight to induce diabetes (using cold 0.1 M citrate buffer pH 4.5). In rats and dogs, diabetes was induced using intravenous dosage of 50 mg/kg body weight (using 1-2% w/v solutions in saline buffered with citrate dextrose solution at pH 5.0).
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.