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Streptozotocin

Streptozotocin

Synonyms N-(Methylnitrosocarbamoyl)-α-D-glucosamine; Streptozocin; STZ; 2-Deoxy-2-(3-methyl-3-nitrosoureido)-D-glucopyranose

CAS Number: 18883-66-4 Molecular Formula: C8H15N3O7 Molecular Weight: 265.222 g/mol

Beilstein Registry Number: 2060675 EC Number: 242-646-8 MDL Number: MFCD00006607

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SKU 02100557-CF
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Description

Product Description

Streptozotocin

Application Notes

Streptozocin is used to induce Type 1 diabetes for medical research. It has been used for the treatment of malignant insulinoma It is used mainly in the treatment of pancreatic (islet-cell) tumors.

Usage Statement

Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.

Key Applications

Treatment of pancreatic (islet-cell) tumors

Specifications
SKU 02100557-CF
Application Notes Streptozocin is used to induce Type 1 diabetes for medical research. It has been used for the treatment of malignant insulinoma It is used mainly in the treatment of pancreatic (islet-cell) tumors.
Beilstein Registry Number 2060675
Biochemical Physiological Actions An N-nitroso-containing compound that acts as a nitric oxide donor in pancreatic islets; induces death of insulin-secreting cells, producing an animal model of diabetes. Potent DNA methylating agent that induces chromosomal breakage. Cytotoxic to neuroendocrine tumor cell lines that express the GLUT2 glucose transporter.
EC Number 242-646-8
Extinction Coefficient EmM(228 nm): 6.36 (ethanol)
Format powder
Half Life biological half-life in cell culture medium was shown to be approximately 19 minutes.
Hazard Statements H350
Applications Treatment of pancreatic (islet-cell) tumors
Melting Point 239° F (Decomposes) (NTP, 1992)
Molecular Formula C8H15N3O7
Molecular Weight 265.222 g/mol
Personal Protective Equipment Eyeshields, full-face particle respirator type N100, Gloves, respirator cartridge, respirator filter
Physical Appearance Off-white powder
Product Families Description Streptozotocin
Product Overview Streptozotocin
Purity ~75% α-anomer basis; ≥97%
RTECS Number LZ5775000
Safety Symbol GHS06+GHS08
Solubility Soluble (NTP, 1992)
Storage and Handling -20°C; desiccate; store under nitrogen
Typical Working Concentration Has been used in intravenous injections in rats at a dose of 65 mg/kg body weight to induce diabetes (using cold 0.1 M citrate buffer pH 4.5). In rats and dogs, diabetes was induced using intravenous dosage of 50 mg/kg body weight (using 1-2% w/v solutions in saline buffered with citrate dextrose solution at pH 5.0).
Usage Statement Research Use Only (RUO). Ready for CE IVD labeling of clinical applications.