Streptomycin Sulfate

Streptomycin Sulfate

Synonyms Streptomycin Sesquisulfate; O-2-Deoxy-2-(methylamino)-a-L- glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-a-L- lyxofuranosyl- (1->4)- N,N'- bis(aminoiminomethyl)-D-streptamine; Streptomycin A

CAS Number: 3810-74-0 Molecular Formula: C42H84N14O36S3 Molecular Weight: 1457.376 g/mol

Beilstein Registry Number: 3894995 EC Number: 223-286-0 MDL Number: MFCD00037023

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SKU 02100556-CF
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Description

Product Description

Streptomycin Sulfate

Application Notes

Streptomycin Sulfate is used to inhibit bacterial protein synthesis at the level of initiation inhibition. It inhibits gram-negative and gram-positive bacteria.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Antibiotic

Specifications
SKU 02100556-CF
Alternate Names Streptomycin Sesquisulfate; O-2-Deoxy-2-(methylamino)-a-L- glucopyranosyl-(1->2)-O-5-deoxy-3-C-formyl-a-L- lyxofuranosyl- (1->4)- N,N'- bis(aminoiminomethyl)-D-streptamine; Streptomycin A
Application Notes Streptomycin Sulfate is used to inhibit bacterial protein synthesis at the level of initiation inhibition. It inhibits gram-negative and gram-positive bacteria.
Beilstein Registry Number 3894995
Biochemical Physiological Actions Mode of Action: Inhibits prokaryote protein synthesis. Binds to S12 protein of 30S ribosomal subunit, preventing the transition from initiation complex to chain-elongating ribosome, causing miscoding or inhibiting initiation. Mode of Resistance: Mutation in rpsL (gene for S12 ribosomal protein) prevents binding of streptomycin to ribosome. Aminoglycoside phosphotransferase also inactivates. Antimicrobial spectrum: Gram-negative and Gram-positive bacteria.
EC Number 223-286-0
Format powder
Half Life half-life in plasma is about 2-4 hours
Hazard Statements H302-H361
Applications Antibiotic
Loss on Drying ≤7.0%
MDL # MFCD00037023
Molecular Formula C42H84N14O36S3
Molecular Weight 1457.376 g/mol
Optical Rotation -77 to -79 ° (c=1% in H2O, 25 °C) (lit.)
Personal Protective Equipment Dust mask, Eyeshields, Faceshields, Gloves
Physical Appearance White Powder
Product Families Description Streptomycin sulfate
Product Overview Streptomycin Sulfate
RTECS Number WK4990000
Safety Symbol GHS07, GHS08
Solubility greater than or equal to 0.1 mg/mL at 64° F (NTP, 1992)
Specific Activity ≥650 u/mg
Storage and Handling +4 °C
Typical Working Concentration Typically used at a concentration of 50-100 mg/liter
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.