Adenosine

Adenosine

Synonyms 9- β-D-Ribofuranosyladenine; Adenine riboside; Adenine-9-β-D-ribofuranoside

CAS Number: 58-61-7 Molecular Formula: C10H13N5O4 Molecular Weight: 267.245 g/mol

Beilstein Registry Number: 93029 EC Number: 200-389-9 MDL Number: MFCD00005752

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SKU 02100199-CF
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Description

Product Description

Adenosine

Application Notes

Adenosine is active in cardiovascular disorders. It is indicated in cases of angina pectoris on account of its property of increasing the coronary output and in cases of hypertension on account of its vasodilator action. It is also active on the peripheral circulation, dilating the capillary vessels. It has also been recommended in the treatment of agranulocytosis. It induces apoptosis in human leukemia HL-60 cells and also has anti-arrhythmic properties.

Usage Statement

Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Key Applications

Treatment of cardiovascular disorders and agranulocytosis

Specifications
SKU 02100199-CF
Alternate Names 9- β-D-Ribofuranosyladenine; Adenine riboside; Adenine-9-β-D-ribofuranoside
Application Notes Adenosine is active in cardiovascular disorders. It is indicated in cases of angina pectoris on account of its property of increasing the coronary output and in cases of hypertension on account of its vasodilator action. It is also active on the peripheral circulation, dilating the capillary vessels. It has also been recommended in the treatment of agranulocytosis. It induces apoptosis in human leukemia HL-60 cells and also has anti-arrhythmic properties.
Beilstein Registry Number 93029
Biochemical Physiological Actions Endogenous neurotransmitter at adenosine receptors. Cardioprotective effects may relate to activation of A1 adenosine receptors. The antiplatelet and anti−inflammatory actions of adenosine appear to be mediated via the A2 adenosine receptor. In contrast, adenosine appears to be a pro-inflammatory mediator in asthma and chronic obstructive pulmonary disease (COPD).
EC Number 200-389-9
Extinction Coefficient 15.4 (259 nm in 0.01 M PO4, pH 7)
Format Free Base; Powder
Gene ID human ... ADA(100), ADORA1(134), ADORA2A(135), ADORA2B(136), ADORA3(140), ERBB2(2064), ERBB4(2066) rat ... Adcy2(81636), Adora1(29290), Adora2a(25369), Adora3(25370)
Hazard Statements H302-H313
Applications Treatment of cardiovascular disorders and agranulocytosis
MDL # MFCD00005752
Melting Point 500 to 518° F (NTP, 1992)
Molecular Formula C10H13N5O4
Molecular Weight 267.245 g/mol
Optical Rotation α20/D -70 °, c = 2 in 5% NaOH (lit.)
Personal Protective Equipment Eyeshields, Gloves, respirator filter
pH pH = 4.5-7.5 (solution of 3 mg/mL adenosine and 9 mg/mL <a class="pubchem-internal-link CID-5234" href="https://pubchem.ncbi.nlm.nih.gov/compound/sodium%20chloride">sodium chloride</a> in <a class="pubchem-internal-link CID-962" href="https://pubchem.ncbi.nlm.nih.gov/compound/water">water</a>)
Physical Appearance White Powder
Product Families Description Adenosine
Product Overview Adenosine
Purity ≥98%
Refractive Index n20D 1.91 (Lit.)
RTECS Number AU7175000
Solubility >40.1 [ug/mL]
Storage and Handling Store at -0 °C.
Usage Statement Research Use Only (RUO). Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
UV Visible Absorbance λmax (1N HCl)-255 - 260 nm OD250/OD260 - 0.80 - 0.90 OD280/OD260 - 0.17 - 0.24
Vapor Pressure 6.0X10-15 mm Hg at 25 deg C (est)