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Caspase 9 is an initiator caspase that cleaves procaspase 3 and procaspase 7 to propagate the apoptotic cascade. Caspase 9 may be detected using a variety of chromogenic and fluorogenic peptide substrates built around the LEHD peptide core such as the chromogenic substrate Ac-LEHD-pNa (Ac-Leu-Glu-His-Asp-p-nitroanalide).
The paranitroanilide substrates are N-acylated derivaties of 4-nitroanilides. Upon cleavage, they release a paranitroanilide group, which has a high absorbance at 410nm (E410nm = 8800M-1cm-1).
Cell Viability Analysis
Proteins, Enzymes & Peptides
Protein or Enzyme Type
Activators, Inhibitors & Substrates
White lyophilized powder
Mass Spec: M+1=675.6 HPLC: 99 ± 1% Sequence-Acetyl-Leu-Glu-His-Asp-PNA