02154165 MP BIOMEDICALS

FIBRINOGEN

from Bovine New Zealand

Off-White Powder

Synonyms Factor I

  • Molecular Weight α-chain mol wt 63.5 kDa, β-chain mol wt 56 kDa, γ chain mol wt 47 kDa (about 4% carbohydrate content)(Lit.)
  • EC Number 232-598-6
  • MDL Number MFCD00163624
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Properties

Keywords Sturctural Proteins, Serum Proteins, Blood, Plasma, Fibrinogen/Fibrin, Inhibitors and Substrates, Clotting factor, Cell Biology, Biochemicals
Key Applications Clotting Factor
Application Areas Cell Biology & Analysis
Product Type Proteins, Enzymes & Peptides
Protein or Enzyme Type Plasma & Blood Proteins

Description

Applications

Fibrinogen has been used in studies of haemostatic therapy in surgical and massive trauma patients. These studies have shown that fibrinogen may prove to be more superior in stopping blood loss when compared to using fresh frozen plasma (FFP).


Product Description

Fibrinogen is a blood protein that is involved in clotting and is converted to fibrin by thrombin. It consists of three non-identical pairs of disulfide bonded chains.


Biochem/physiol Actions

Fibrinogen is an acute phase protein that is part of the coagulation cascade of proteins. The end result of the cascade is the production of thrombin that converts fibrinogen to fibrin. Thrombin rapidly proteolyzes fibrinogen, releasing fibrinopeptide A. The loss of this small peptide is not sufficient to make the resulting fibrin molecule insoluble, but it tends to form complexes with adjacent fibrin and fibrinogen molecules. Thrombin then cleaves a second peptide, fibrinopeptide B, from fibrin and the fibrin monomers formed then polymerize spontaneously to form an insoluble gel. The polymerized fibrin is held together by noncovalent and electrostatic forces and stabilized by the transamidating enzyme, factor XIIIa, that is produced by the action of thrombin on factor XIII. The insoluble fibrin aggregates (clots) and aggregated platelets then block the damaged blood vessel and prevent further bleeding. The amount of fibrinogen in the plasma can serve as a nonspecific indicator of whether or not an inflammatory process is present in the body. Fibrinogen from any mammalian source will be cleaved by thrombin from any mammalian source.


Price and Availability

SKU-Pack Size Availability Price (USD) Quantity
0215416501 - 1 g In Stock 153.40
0215416505 - 5 g In Stock 450.75
0215416525 - 25 g In Stock 1,214.50

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Protocols & References

Ratings & Reviews

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