02153842 MP BIOMEDICALS

VITRONECTIN

from Bovine

White Powder

Synonyms Serum spreading factor

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Description

Applications

Vitronectin can be used with cells with integrin receptors that bind vitronectin, including platelets, endothelial cells, melanoma cells, and osteosarcoma. It is recommended as a cell culture substratum at 0.1 µg/cm2. Optimal conditions for attachment depend on cell line and application.


Product Description

Vitronectin is a glycoprotein present in plasma and tissues, and is one of the major cell adhesion proteins, along with fibronectin, in plasma. The N-terminal residues of vitronectin are identical to somatomedin B and are followed by an R-G-D sequence that interacts with a specific cell-surface receptor. The central domain of vitronectin is enriched with hydrophobic residues. Closer to the C-terminus, it has an arginine rich region that allows for heparin binding activity.


Biochem/physiol Actions

Vitronectin binds to glycosaminoglycans, is incorporated as an inhibitor to the membrane cytolytic attack complex of the complement system, has interaction with thrombin and antithrombin III during coagulation, and may play a role in the coagulation pathway.


Properties

Keywords 2D Cell Culture, Adhesion, Attachment, and Matrix Factors, Adhesion, Attachment, and Matrix Factors for Stem Cell Expansion, Application Index, Attachment Factors, Attachments Factors, Biochemicals and Reagents, Cell Biology, Cell Culture, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Core Bioreagents, Cytoskeleton and Extracellular Matrix, ECM Proteins, Enzymes, Inhibitors, and Substrates, Extracellular Matrix, Extracellular Matrix Peptides and Proteins, General Stem Cell Biology, Life Science Reagents for Cell Culture, Matrix Metalloproteinases Products, Proteins and Derivatives, Reagents and Supplements, Research Essentials, Stem Cell Biology, Stem Cell Differentiation, Stem Cell Expansion, Structural Proteins, Vitronectin
Product Type Biochemicals
Presentation White Powder
Format Powder
NOTES

Price and Availability

SKU-Pack Size Availability Price (USD) Quantity
0215384250 - 50 μg In Stock 290.00

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