02153053 MP BIOMEDICALS
ARG-GLY-ASP-SER

White Powder

Synonyms RGDS

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Properties

Keywords Bioactive Small Molecules, Biochemicals and Reagents, Cell Biology, Cell Signaling Enzymes, Cell Signaling and Neuroscience, Cytoskeleton and Extracellular Matrix, ECM Proteins, Enzymes, Inhibitors, and Substrates, Extracellular Matrix, Extracellular Matrix Peptides (ECM), Extracellular Matrix Peptides and Proteins, Fibronectin Fragments and Analogs, Matrix Metalloproteinases Products, Peptides and Proteins, Peptides for Cell Biology
Product Type Biochemicals
Presentation White Powder
Format Powder
Solubility Soluble in water (1 mg/mL - clear colourless solution).

Description

Applications

The tetrapeptide Arg-Gly-Asp-Ser (RGDS) has been shown to block fibrinogen-induced aggregation of intact erythrocytes and specific binding of fibrinogen to erythrocyte membranes. The effect of RGDS on transforming growth factor β1 (TGF1) mRNA expression and secretion in cultured human mesangial cells has been investigated. RGDS has been utilized in a study of integrin-mediated signal transduction in cultured cells from the sponge Suberites domuncula. RGDS has been demonstrated to mitigate the binding of Mycobacterium tuberculosis to murine alveolar macrophages. It inhibits fibronectin binding to platelets.


Product Description

The tetrapeptide Arg-Gly-Asp-Ser (RGDS) is a key component of the cell attachment domain of fibronectin. The RGDS sequence was found initially to promote the attachment of rat kidney fibroblasts (NRK cells) to fibronectin and synthetic fibronectin peptides coupled to protein-coated plastic. Further investigation indicated that the free RGDS peptide inhibited the attachment of NRK cells to fibronectin coated substrates. The RGDS sequence has been shown to occur in several other proteins, such as the receptor on E. coli and the Sindbis coat protein. RGDS is also a target sequence for spirochete adherence of the syphilis bacterium Treponema pallidum.


Price and Availability

SKU-Pack Size Availability Price (USD) Quantity
0215305302 - 2 mg In Stock 51.55
0215305305 - 5 mg In Stock 103.70
0215305310 - 10 mg In Stock 178.55

Safety & Documentation

Protocols & References

Ratings & Reviews

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