from Microbial

≥94%, ~800 ug/mg, White Powder

Synonyms Acti-Dione, 3-[2-(3,5-Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl] glutarimide, Naramycin A

  • CAS Number 66-81-9
  • Molecular Formula C15H23NO4
  • Molecular Weight 281.4
  • Beilstein Registry Number 88868
  • EC Number 200-636-0
  • MDL Number MFCD00082346
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Cycloheximide is used in protein synthesis in apoptosis. It is also used in plant research to study disease resistance and as an ethylene stimulant, useful in studies involving fruit and leaf production.

Product Description

Cycloheximide is an antibiotic which is very active against many molds, yeasts, and phytopathogenic fungi. It exhibits somewhat lower activity against bacteria and certain fungi. It inhibits peptide synthesis in eukaryotic organisms but not in prokaryotes. Protein synthesis is blocked by the interaction of cycloheximide with the translocase enzyme. This interaction prohibits the translocation of messenger RNA on the cytosolic, 80S ribosomes without inhibiting organelle protein synthesis.

Biochem/physiol Actions

Biological activity of Cycloheximide is translation inhibition in eukaryotes resulting in cell growth arrest and cell death.It is known to induce FAS/FAS Ligand apoptosis, and triggers apoptosis in HL-60 cells, T-cell hybridomas, Burkitt's lymphoma cells( Waring, P., "DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels ( J. Biological Chemistry, v. 265:24, 14476-14480 (1990)) in addition to a variety of other cell types. Cycloheximide will also delay or inhibit apoptosis induced by other agents.


Purity ≥94%
Specific Activity ~800 ug/mg
Keywords Antibiotics, Gene expression, steroidogenesis Studies, Disease resistance Studies
Key Applications Gene expression
steroidogenesis Studies
Disease resistance Studies
Product Type Biochemicals

Price and Availability

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