Tuberculosis (TB) is a highly contagious and a high social burden disease. Left undiagnosed and untreated, each patient with TB disease may infect on average between 10 and 15 other people every year. According to WHO, someone in the world is newly infected with TB bacilli every second; overall, one-third of the world's population is currently infected with the TB bacillus, 5-10% of people who are infected with TB bacilli become sick or infectious at some time during their life. It is estimated that 1.6 million deaths resulted from TB in 2005. The number of new cases arising each year is increasing globally and more specifically in the regions of Africa, the Eastern Mediterranean and Asia. Situations such HIV- TB, Multi-drug resistant TB makes the challenge more complex.