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Events Calendar

Dec 07

24th Meeting of the French Society of Toxinology (SFET)

Dec 07, 2017

Institut Pasteur, Paris, FRANCE

Dec 14

Molecular Microbial Ecology Group Meeting (MMEG 2017)

Dec 14, 2017

University of Warwick. Coventry, UK

Penetratin™: your vector for non-traumatic internalization of hydrophilic compounds into Eukaryotic cells

Penetratin™ is a patented 16-amino acid peptide corresponding to the third helix homeodomain of Drosophila Antennapedia (pAntp) protein. This peptide is able to translocate across biological membranes by an energy-independent mechanism.

With the use of Penetratin™ peptide, covalently attached peptides, Oligonucleotides and siRNA are internalized and conveyed to the cytoplasm and nucleus in a wide variety of cell lines.

The activated Penetratin™ Peptide features a pyridyl disulfide function at its N-terminal end. The molecule to be coupled must have a free thiol group (-SH) available (i.e. a cysteine in the case of peptides).

E18 primary rat hippocampal neurons were treated with siRNA targeting the X-linked inhibitor of apoptosis protein (XIAP) alone (left) or complexed to Penetratin™ 1 (right). 24 hours later RNAi was detected by staining for XIAP (green). Cells were stained for cytochrome c as a control (red).

Note:1 Courtesy of Dr. C.M. Troy, Columbia University Medical Center, New York. The Journal of Neuroscience, November 10, 2004 • 24(45):10040 - 10046

Products included in this offer:

SKU Product Name Size Promo List Price Sale Price Availability Quantity
11PENA0500 ACTIVATED PENETRATIN™ 500 μg - $537.50 - Inquire
11PENB0500 Biotinylated Penetratin 500 μg - $584.00 - Inquire