Contact Us

(800) 854-0530

Hours of Operation:

8:00 AM - 7:00 PM EST

Events Calendar

Nov 06

ASA 2016

Nov 06, 2016

Phoenix, AZ

Nov 06

NCRI Cancer Conference 2016

Nov 06, 2016

Liverpool, UK

Nov 07

Rapid Methods Europe 2016

Nov 07, 2016

Amsterdam, The Netherlands

Penetratin™: your vector for non-traumatic internalization of hydrophilic compounds into Eukaryotic cells

Penetratin™ is a patented 16-amino acid peptide corresponding to the third helix homeodomain of Drosophila Antennapedia (pAntp) protein. This peptide is able to translocate across biological membranes by an energy-independent mechanism.

With the use of Penetratin™ peptide, covalently attached peptides, Oligonucleotides and siRNA are internalized and conveyed to the cytoplasm and nucleus in a wide variety of cell lines.

The activated Penetratin™ Peptide features a pyridyl disulfide function at its N-terminal end. The molecule to be coupled must have a free thiol group (-SH) available (i.e. a cysteine in the case of peptides).

E18 primary rat hippocampal neurons were treated with siRNA targeting the X-linked inhibitor of apoptosis protein (XIAP) alone (left) or complexed to Penetratin™ 1 (right). 24 hours later RNAi was detected by staining for XIAP (green). Cells were stained for cytochrome c as a control (red).

Note:1 Courtesy of Dr. C.M. Troy, Columbia University Medical Center, New York. The Journal of Neuroscience, November 10, 2004 • 24(45):10040 - 10046

Products included in this offer:

SKU Product Name Size List Price Sale Price Availability Quantity
11PENA0500 ACTIVATED PENETRATIN 1 500 μg $511.90 $511.90 Inquire
11PENB0500 BIOTINYLATED PENETRATIN 1 500 μg $584.00 $584.00 Inquire