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Ribavirin

Catalog Number: 196066
Ribavirin


Structure:



Molecular Formula: C8H12N4O5

Molecular Weight: 244.2

CAS # 36791-04-5

Synonym: 1-b-D-Ribofuranosyl-1,2,4-triazole-3-carboxamide

Solubility: Soluble in water (20 mg/ml - clear, colorless solution).

Description: An antiviral compound reported to be active against RSV, HIV, HCV and other infectious agents. Its metabolite, ribavirin 5'-phosphate, inhibits inosine monophosphate dehydrogenase (IMP).

References:

  1. Honda, Y., et al., "Effect of ribavirin on subacute sclerosing panencephalitis virus infections in hamsters." Antimicrob. Agents Chemother., v. 38, 653 (1994).
  2. Liao, H.J. and Stoller, V., "Reversal of the antiviral activity of ribavirin against Sindbis virus in Ae. albopictus mosquito cells." Antiviral Res., v. 22, 285 (1993).
  3. "Schering-Plough's Rebetron Combination Therapy gets FDA approval for treatment of chronic hepatitis C virus infection in patients with compensated liver disease previously untreated with alpha interferon." Antiviral Agents Bulletin (1998).
  4. Rodriguez, W.J., Arrobio, J., Fink, R., Kim, H.W., Milburn, C., "Prospective follow-up and pulmonary functions from a placebo-controlled randomized trial of ribavirin therapy in respiratory syncytial virus bronchiolitis. Ribavirin Study Group." Arch. Pediatr. Adolesc. Med., v. 153: 5, 469-474 (1999).
  5. Khakoo, S., et al., "Ribavirin and interferon alfa-2b in chronic hepatitis C: assessment of possible pharmacokinetic and pharmacodynamic interactions." Br. J. Clin. Pharmacol., v. 46:6, 563-570 (1998).
  6. Dusheiko, G., et al., "Ribavirin treatment for patients with chronic hepatitis C: results of a placebo-controlled study." J. Hepatol., v. 25:5, 591-598 (1996).
  7. Gilbert, B.E., Wyde, P.R., Wilson, S.Z., Robins, R.K., "Aerosol and intraperitoneal administration of ribavirin and ribavirin triacetate: pharmacokinetics and protection of mice against intracerebral infection with influenza A/WSN virus." Antimicrob. Agents Chemother., v. 35:7, 1448-1453 (1991).
  8. Jarvis, S.M., Thorn, J.A., Glue, P., "Ribavirin uptake by human erythrocytes and the involvement of nitrobenzylthioinosine-sensitive (es)-nucleoside transporters." Br. J. Pharmacol., v. 123:8, 1587-1592 (1998).
  9. Thevenot, T., et al., "Effects of cirrhosis, interferon and azathioprine on adverse events in patients with chronic hepatitis C treated with ribavirin." J. Viral Hepat., v. 4:4, 243-253 (1997).
  10. Moler, F.W., Steinhart, C.M., Ohmit, S.E., Stidham, G.L., "Effectiveness of ribavirin in otherwise well infants with respiratory syncytial virus-associated respiratory failure. Pediatric Critical Study Group." J. Pediatr., v. 128:3, 422-428 (1996).